Mechanotransduction in vascular physiology and atherogenesis

[Role of shear stress and endothelial mechanotransduction in atherogenesis].

WSTĘP Pomiędzy krwią a ścianą naczynia zachodzi nieprzerwana interakcja, zależna od ciśnienia tętniczego i zmiennej prędkości przepływu związanej z cyklicznością pracy serca. Z przepływem wiążą się naprężenia ścinające działające na komórki śródbłonka. Odpowiedzią naczynia na nieprawidłowe naprężenia ścinające jest zmiana architektury śródbłonka i zaburzenia jego czynności. Za pośrednictwem mec...

Forces and mechanotransduction in 3D vascular biology.

The effects of hemodynamic and interstitial mechanical forces on endothelial biology in vivo have been appreciated for over half a century, regulating vessel network development, homeostatic function, and progression of vascular disease. Investigations using cultures of endothelial cells on two-dimensional (2D) substrates have elucidated important mechanisms by which microenvironmental stresses...

Atherogenesis and Vascular Disease in SLE

Mechanotransduction Mechanisms in Mitral Valve Physiology and Disease Pathogenesis

The mitral valve exists in a mechanically demanding environment, with the stress of each cardiac cycle deforming and shearing the native fibroblasts and endothelial cells. Cells and their extracellular matrix exhibit a dynamic reciprocity in the growth and formation of tissue through mechanotransduction and continuously adapt to physical cues in their environment through gene, protein, and cyto...

Cell mechanics and mechanotransduction: pathways, probes, and physiology.

Cells face not only a complex biochemical environment but also a diverse biomechanical environment. How cells respond to variations in mechanical forces is critical in homeostasis and many diseases. The mechanisms by which mechanical forces lead to eventual biochemical and molecular responses remain undefined, and unraveling this mystery will undoubtedly provide new insight into strengthening b...